The influence of changes in lipid values induced by cholestyramine and diet on progression of coronary artery disease: results of NHLBI Type II Coronary Intervention Study.
نویسندگان
چکیده
The National Heart, Lung and Blood Institute Type II Coronary Intervention Study, a double-blind, placebo-controlled trial, evaluated the efficacy of reduction in cholesterol levels induced by cholestyramine on progression of coronary artery disease (CAD). The rate of CAD progression in patients treated with cholestyramine plus diet was compared with that of patients treated with placebo plus diet. CAD progression was defined angiographically. Significant decrease in total cholesterol (TC) and low-density lipoprotein cholesterol (LDLc) and increases in high-density lipoprotein cholesterol (HDLc), as well as in HDLc/TC and HDLc/LDLc ratios, were observed with cholestyramine. HDLc change was due to increase in HDL2A and HDL2B. When the relationship between CAD progression and lipid changes was examined independent of specific treatment group, a significant inverse relationship was found between progression at 5 years and the combination of an increase in HDLc and a decrease in LDLc; changes in HDLc/TC and HDLc/LDLc were the best predictors of CAD change. While the testing of these relationships independent of treatment group was not part of the initial study design, the trends were observed in both the placebo-treated and cholestyramine-treated groups. Moreover, with multivariate analysis, the effect of cholestyramine treatment on CAD progression was eliminated by adding changes in HDLc/TC to the regression model. These findings support the hypothesis that increases in HDLc and decreases in TC (or LDLc) can prevent or delay CAD progression.
منابع مشابه
THERAPY AND PREVENTION CORONARY ARTERY DISEASE Effects of therapy with cholestyramine
In the National Heart, Lung and Blood Institute Type Il Coronary Intervention Study, patients with Type lI hyperlipoproteinemia and coronary artery disease (CAD) were placed on a lowfat, low-cholesterol diet and then were randomly allocated to receive either 6 g cholestyramine four times daily or placebo. This double-blind study evaluated the effects of cholestyramine on the progression of CAD ...
متن کاملبررسی شیوع همزمانی عوارض میکروواسکولار و بیماری عروق کرونر در بیماران مبتلا به دیابت تیپ II
Abstract Abstract: Diabetic Mellitus (DM) is a systemic disease that affects all body organs. Micro and macro vascular complications progress with diabetes progression. It is important to find a solution for early diagnosis of coronary artery disease that is a major cause of death in these patients. The goal of this study is to assess the relation between diabetic nephropathy and retinopathy to...
متن کاملبررسی سطح لیپیدها و لیپوپروتئینهای سرم خون در بیماران مبتلا به دیابت ملیتوس تیپ 2 با گرفتگی عروق کرونر STUDY OF SERUM LIPID AND LIPOPROTEIN LEVELS IN PATIENTS WITH CORONARY ARTERY DISEASE AND TYPE 2 DIABETES MELLITUS
ABSTRACT Coronary artery disease (CAD) is the leading cause of death among non-insulin dependant diabetic (NIDDM) Patients. One of risk factor for CAD in dyslipidemia. In regards to high prevalence of NIDDM and CAD among our people, in the present study, levels of lipids and lipoproteins in two groups of patients, CAD+/NIDDM+ group and CAD+/NIDDM- group, were evaluated and compared. ...
متن کاملPredictors of Diet Self-efficacy in Coronary Artery Disease Patients
Introduction: Coronary artery disease is one of the most prevalent cardiovascular diseases in developed countries. Following a healthy diet and lifestyle decline emergence of the disease complication and readmission rate due to unstable angina and myocardial infarction. Promotion of self-efficacy after a cardiovascular event is the outcome that plays a vital role in increasing rehabilitation sk...
متن کاملLipid Profiles and Prevalence of Dyslipidemia in Eastern Iranian Adolescents, Birjand, 2012
Background: Cardiovascular risk factors begin in childhood and adolescence. This study aimed at assessing serum lipids and prevalence of Dyslipidemia in 11-18 year old students of Birjand.Method: The present cross-sectional, descriptive, and analytical study was done on 2,643 middle and high school students of Birjand aged 11-18 years (1,396 girls and 1,247 boys). Blood samples were collected f...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Circulation
دوره 69 2 شماره
صفحات -
تاریخ انتشار 1984